Light-controlled toxicity of engineered amyloid β-peptides.
نویسندگان
چکیده
Aggregation of amyloid β (Aβ(1-42)), causing toxicity, is a critical step in Alzheimer's disease (AD). AD studies are difficult to compare because Aβ(1-42) aggregation is poorly controllable under physiological conditions. To control aggregation and toxicity, we engineered light-switchable Aβ(1-42) analogues that enable controllable conversion of nontoxic fibrils into toxic oligomers simply by illumination.
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ورودعنوان ژورنال:
- Chembiochem : a European journal of chemical biology
دوره 13 18 شماره
صفحات -
تاریخ انتشار 2012